BREEDER’S BLOG

What is a Genetic Map and Why Is It Important For Plant Molecular Breeding?

In one of our previous posts, we introduced the concept of “genetic mapping”.

🔎Simply put, it is the process of determining a) the order of genes and DNA markers along a chromosome and, b) the genetic distance between them, measured in centimorgans (cM).
This is done by analyzing the recombination frequencies observed in the offspring of crosses between genetically diverse parents. The more often two markers are separated during recombination, the further apart they are on the map.

🧬📍The result of this process is a “genetic map”, also called a linkage map. It is a graphical representation of a chromosome that displays two features:
->The order in which the markers are located in the genome
->The genetic distances between them, reflecting their recombination frequency, and starting from 0 cM at the top-first marker of the chromosome.

🤔You can think of it as a “GPS” of the genome, where markers are placed in the order they appear, and the distance between them reflects how often they get separated during meiosis.

For plant breeders and plant geneticits, genetic maps are very practical because they allow:

1️⃣ Developing marker traits (or doing QTL mapping) – locating genes or regions that control yield, disease resistance, quality, and more.
2️⃣ Designing the logistics of marker selection schemes – for instance, which flanking and background markers to use for transferring useful traits into elite breeding material and recovering the genetic background of the recurrent parent.
4️⃣Connecting with DNA sequence data – linking genetic information for assembling genomes or identifying candidate genes within a QTL region.
5️⃣Isolating useful genes by positional cloning– helping isolate and characterize genes that control traits of high value.

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